Testing Adaptive Interventions to Improve PTSD Treatment Outcomes in Federally Qualified Health Cent

Led by Dr. Sripada at the University of Michigan, this study establishes the effectiveness of an adaptive, stepped-care intervention for PTSD that will have the greatest impact on patients’ lives and functioning, using a Sequential, Multiple Assignment, Randomized Trial (SMART) design with two-stage randomization. Our central hypothesis is that beginning with a low- or medium-intensity PTSD intervention and then stepping up to a higher-intensity intervention for slow treatment responders will result in clinically significant PTSD symptom reduction.